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David M Roth Selected Research

Caveolin 3

1/2020Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy.
1/2019Cardiac-specific overexpression of caveolin-3 preserves t-tubular ICa during heart failure in mice.
11/2018Caveolin-3 KO disrupts t-tubule structure and decreases t-tubular ICa density in mouse ventricular myocytes.
12/2016Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion.
9/2015Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase Cα in Cardiomyocytes.
5/2011Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling.
3/2011Role of caveolae in cardiac protection.
5/2010Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection.
1/2008Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury.

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David M Roth Research Topics

Disease

12Ischemia
11/2021 - 02/2006
10Heart Failure
03/2019 - 07/2004
10Infarction (Infarctions)
10/2013 - 05/2002
9Reperfusion Injury
04/2015 - 03/2006
6Cardiomyopathies (Cardiomyopathy)
01/2020 - 04/2002
5Myocardial Ischemia (Ischemic Heart Diseases)
03/2011 - 06/2004
3Heart Diseases (Heart Disease)
01/2020 - 01/2012
3Hypertrophy
05/2011 - 07/2006
3Myocardial Infarction
04/2008 - 08/2006
2Pain (Aches)
11/2021 - 01/2018
2Inflammation (Inflammations)
11/2021 - 01/2015
2Fibrosis (Cirrhosis)
01/2020 - 04/2010
2Traumatic Brain Injuries (Traumatic Brain Injury)
01/2017 - 03/2014
2Cardiomegaly (Heart Hypertrophy)
09/2015 - 05/2011
2Pulmonary Hypertension
06/2014 - 01/2012
2Colonic Neoplasms (Colon Cancer)
11/2012 - 09/2011
2Cognitive Dysfunction
02/2012 - 04/2009
2Hypoxia (Hypoxemia)
01/2008 - 05/2007
2Hypothermia
07/2004 - 04/2004
1Critical Illness (Critically Ill)
11/2021
1Memory Disorders (Memory Loss)
06/2021
1Diabetes Mellitus
01/2021
1Muscular Diseases (Myopathy)
01/2019
1Waterborne Diseases
11/2017
1Cardiotoxicity
01/2017
1Schizophrenia (Dementia Praecox)
01/2017
1Starvation
12/2016
1Left Ventricular Dysfunction
10/2016
1Neuroinflammatory Diseases
03/2014
1Lung Injury
01/2012
1Cardiovascular Diseases (Cardiovascular Disease)
01/2012
1Neoplasms (Cancer)
09/2011
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
04/2010

Drug/Important Bio-Agent (IBA)

10CaveolinsIBA
01/2017 - 11/2008
9Caveolin 3IBA
01/2020 - 01/2008
7IsofluraneFDA LinkGeneric
09/2011 - 03/2006
7Adenylyl Cyclases (Adenylyl Cyclase)IBA
04/2010 - 04/2002
6Caveolin 1IBA
06/2021 - 05/2007
6Proteins (Proteins, Gene)FDA Link
06/2021 - 06/2004
6Anesthetics (Anesthetic Agents)IBA
09/2011 - 05/2007
4adenylyl cyclase 6IBA
04/2010 - 04/2002
2Membrane LipidsIBA
06/2021 - 01/2017
2Opioid Receptors (Opioid Receptor)IBA
01/2021 - 11/2010
2IntegrinsIBA
01/2017 - 10/2013
2Caspase 3 (Caspase-3)IBA
12/2016 - 03/2006
2CytokinesIBA
01/2015 - 01/2012
2CholesterolIBA
09/2014 - 07/2006
2LigandsIBA
09/2014 - 09/2011
2Protein Isoforms (Isoforms)IBA
03/2011 - 07/2006
2SNC 121IBA
11/2010 - 09/2007
2CollagenIBA
04/2010 - 04/2008
2methyl-beta-cyclodextrinIBA
01/2008 - 07/2006
2CalciumIBA
08/2006 - 11/2004
2Messenger RNA (mRNA)IBA
06/2004 - 05/2002
13,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA
01/2020
1Adrenergic Agents (Adrenergic Drugs)IBA
01/2020
1Inositol (Myoinositol)IBA
03/2019
1Phospholipids (Phosphatides)FDA LinkGeneric
03/2019
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
01/2019
1Analgesics (Analgesic Drugs)IBA
01/2018
1Drinking WaterIBA
11/2017
1Daunorubicin (Cerubidine)FDA LinkGeneric
01/2017
1Synapsins (Synapsin I)IBA
01/2017
1AnthracyclinesIBA
01/2017
1Sirolimus (Rapamycin)FDA Link
12/2016
1Beclin-1IBA
12/2016
1Cytochromes c (Cytochrome c)IBA
12/2016
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
10/2016
1Indicators and Reagents (Reagents)IBA
10/2016
1Adrenergic Receptors (Adrenergic Receptor)IBA
10/2016
1CalcineurinIBA
09/2015
1Protein Kinases (Protein Kinase)IBA
09/2015
1Protein Kinase CIBA
09/2015
1Angiotensin IIIBA
09/2015
1Morphine (MS Contin)FDA LinkGeneric
09/2014
1Vasopressins (Vasopressin)IBA
06/2014
1Peptides (Polypeptides)IBA
09/2013
1Propofol (Diprivan)FDA LinkGeneric
02/2012
1SteroidsIBA
01/2012
1MethylprednisoloneFDA LinkGeneric
01/2012
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2011
1Natriuretic PeptidesIBA
05/2011
1Death Domain ReceptorsIBA
04/2011
1Narcotic Antagonists (Opioid Antagonists)IBA
11/2010
1Naloxone (Narcan)FDA LinkGeneric
11/2010
1norbinaltorphimineIBA
11/2010
1Opioid Analgesics (Opioids)IBA
11/2010
1Catechin (Z 7300)IBA
11/2010
1RNA (Ribonucleic Acid)IBA
04/2010
1PeriostinIBA
04/2010
1Phosphatidylinositols (Phosphatidylinositol)IBA
11/2008
1Transforming Growth Factors (Transforming Growth Factor)IBA
04/2008
1Dizocilpine Maleate (Dizocilpine)IBA
03/2008

Therapy/Procedure

2Therapeutics
04/2015 - 03/2011
2Endarterectomy (Thromboendarterectomy)
06/2014 - 01/2012
2Ligation
11/2007 - 08/2006
1Critical Care (Surgical Intensive Care)
11/2021
1Perioperative Period
11/2021
1Pain Management
11/2021
1Liver Transplantation
01/2020